Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 18/20 | 0.58 |
| ▸ | RARB | P10826 | 17/20 | 0.58 |
| ▸ | RARA | P10276 | 15/20 | 0.58 |
| ▸ | RXRA | P19793 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460959 | 1.00 | RARG (0.58) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL901112 | 0.84 | ALDH1A1 (0.68) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL901113 | 0.84 | ALDH1A1 (0.68) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL409466 | 0.81 | RARG (0.56) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL409465 | 0.81 | RARG (0.56) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL9342916 | 0.80 | RARG (0.51) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL9342915 | 0.80 | RARG (0.51) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL9268290 | 0.78 | RARG (0.57) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL29421064 | 0.78 | CES2 (0.63) | ALDH1A1POLBKDM4ENPC1LMNA | |
| SCHEMBL310259 | 0.78 | CES2 (0.63) | ALDH1A1POLBKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |