Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183230 | 0.87 | MAOB (0.53) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL9520014 | 0.83 | CYP3A4 (0.64) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8462064 | 0.82 | CYP3A4 (0.56) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8461434 | 0.81 | MAOB (0.70) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8888420 | 0.80 | MTNR1A (0.44) | MAPTMEN1KMT2ATP53LOXL2 | |
| SCHEMBL8466024 | 0.79 | MAOB (0.54) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL6999719 | 0.78 | MAOB (0.54) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8461238 | 0.78 | MAOB (0.41) | MAOBCYP3A4MAPTMEN1KMT2A | |
| SCHEMBL8465636 | 0.77 | LTB4R (0.50) | CYP3A4USP2LOXL2 | |
| SCHEMBL8465638 | 0.77 | LTB4R (0.50) | CYP3A4USP2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5298512-A | Substituted chromans and their use in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0391625-B1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1994-01-26 | — | — | EP | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5149703-A | Anti-asthma, allergen and inflammatory agents, cyctoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-09-22 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| WO-1990012010-A1 | SUBSTITUTED CHROMANS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-10-18 | — | — | WO | disclosed |
| EP-0391625-A1 | Substituted chromans in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1990-10-10 | — | — | EP | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |