Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 7/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8464260 | 1.00 | LTB4R (0.66) | LTB4RPDE10ACYP19A1ALOX5APALOX5 | |
| SCHEMBL8466345 | 1.00 | LTB4R (0.66) | LTB4RPDE10ACYP19A1ALOX5APALOX5 | |
| SCHEMBL8466153 | 0.94 | LTB4R (0.67) | LTB4RPDE10AALOX5AP | |
| SCHEMBL8465764 | 0.91 | LTB4R (0.53) | LTB4RPDE10AALOX5 | |
| SCHEMBL8461585 | 0.86 | PDE10A (0.50) | LTB4RPDE10AALOX5APALOX5 | |
| SCHEMBL8462119 | 0.85 | LTB4R (0.47) | LTB4RPDE10AALOX5 | |
| SCHEMBL8465629 | 0.83 | LTB4R (0.53) | LTB4RPDE10ACYP19A1ALOX5AP | |
| SCHEMBL8523093 | 0.83 | LTB4R (0.55) | LTB4RPDE10ACYP19A1ALOX5 | |
| SCHEMBL8461564 | 0.83 | LTB4R (0.55) | LTB4RPDE10ACYP19A1ALOX5APALOX5 | |
| SCHEMBL9326026 | 0.82 | LTB4R (0.65) | LTB4RCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |