Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465764 | 0.89 | LTB4R (0.53) | PDE10ALTB4RALOX5CYSLTR1GPBAR1 | |
| SCHEMBL8348183 | 0.87 | LTB4R (0.43) | PDE10ALTB4R | |
| SCHEMBL8464260 | 0.86 | LTB4R (0.66) | PDE10ALTB4RALOX5ALOX5AP | |
| SCHEMBL8466345 | 0.86 | LTB4R (0.66) | PDE10ALTB4RALOX5ALOX5AP | |
| SCHEMBL8464264 | 0.86 | LTB4R (0.66) | PDE10ALTB4RALOX5ALOX5AP | |
| SCHEMBL8462119 | 0.85 | LTB4R (0.47) | PDE10ALTB4RALOX5CYSLTR1GPBAR1 | |
| SCHEMBL9520559 | 0.83 | PDE10A (0.49) | PDE10ALTB4RALOX5ALOX5APCYSLTR1 | |
| SCHEMBL8030940 | 0.83 | ALOX5 (0.45) | PDE10ALTB4RALOX5CYSLTR1GPBAR1 | |
| SCHEMBL8029254 | 0.83 | GPBAR1 (0.53) | PDE10ALTB4RALOX5CYSLTR1GPBAR1 | |
| SCHEMBL8465611 | 0.82 | MAOB (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |