Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8466345 | 0.91 | LTB4R (0.66) | LTB4RALOX5PDE10A | |
| SCHEMBL8464260 | 0.91 | LTB4R (0.66) | LTB4RALOX5PDE10A | |
| SCHEMBL8464264 | 0.91 | LTB4R (0.66) | LTB4RALOX5PDE10A | |
| SCHEMBL8462119 | 0.90 | LTB4R (0.47) | LTB4RMAOBALOX5CYSLTR1CYSLTR2 | |
| SCHEMBL8464485 | 0.90 | MAOB (0.47) | LTB4RMAOBALOX5CYSLTR1CYSLTR2 | |
| SCHEMBL8461585 | 0.89 | PDE10A (0.50) | LTB4RALOX5CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9520446 | 0.88 | CYSLTR1 (0.54) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8465452 | 0.86 | LTB4R (0.50) | LTB4RALOX5CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8466153 | 0.84 | LTB4R (0.67) | LTB4RPDE10A | |
| SCHEMBL8030940 | 0.84 | ALOX5 (0.45) | LTB4RALOX5CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |