SCHEMBL8464752

SCHEMBL8464752

O=C1c2ccccc2C(=O)c2c1nc1c(Cl)cccn21

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.59
HSP90AB1 P08238 1/20 0.59
AKT1 P31749 1/20 0.43
AKT2 P31751 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
ALDH1A1 P00352 2/20 0.41
NPC1 O15118 1/20 0.41
MAPT P10636 1/20 0.41
AHR P35869 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAOB P27338 1/20 0.41
TDO2 P48775 9/20 0.41
IDO1 P14902 8/20 0.41
GLA P06280 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
NR1H2 P55055 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465447 0.90 HSP90AA1 (0.47) HSP90AA1HSP90AB1AKT1AKT2ALDH1A1
SCHEMBL1274825 0.74 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1HPGD
SCHEMBL8464947 0.72 KDM4E (0.48) HSP90AA1HSP90AB1AKT1AKT2CYP1A2
SCHEMBL8465227 0.70 HSP90AA1 (0.63) HSP90AA1HSP90AB1AKT1AKT2CYP1A2
SCHEMBL23917098 0.67 PTPN1 (0.53) ALDH1A1MAPTSMN1; SMN2GLAGAA
SCHEMBL8464828 0.66 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL31237216 0.66 HSP90AA1 (0.61) HSP90AA1HSP90AB1
SCHEMBL2488727 0.66 HSD11B1 (0.47) AKT1AKT2ALDH1A1NPC1MAPT
SCHEMBL18293598 0.66 AKT1 (0.47) AKT1AKT2CYP1A2CYP3A4CYP2C19
SCHEMBL11446978 0.66 AKT1 (0.47) AKT1AKT2CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed