SCHEMBL8465227

SCHEMBL8465227

O=C1c2ccccc2C(=O)c2c1nc1ccc(Cl)cn21

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.63
HSP90AB1 P08238 1/20 0.63
TP53 P04637 1/20 0.48
GAA P10253 1/20 0.48
TDO2 P48775 3/20 0.47
IDO1 P14902 2/20 0.47
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
MAPT P10636 1/20 0.45
AHR P35869 1/20 0.45
RAB9A P51151 1/20 0.45
PARP1 P09874 1/20 0.44
AKT1 P31749 1/20 0.43
AKT2 P31751 1/20 0.43
CYP1A2 P05177 3/20 0.42
CYP2C19 P33261 3/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8468193 0.91 HSP90AA1 (0.51) HSP90AA1HSP90AB1TP53GAATDO2
SCHEMBL8464922 0.83 HSP90AA1 (0.44) HSP90AA1HSP90AB1TP53GAAALDH1A1
SCHEMBL8466658 0.83 HSP90AA1 (0.44) HSP90AA1HSP90AB1TP53GAAALDH1A1
SCHEMBL8464925 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1TP53GAATDO2
SCHEMBL8465390 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1TDO2IDO1ALDH1A1
SCHEMBL13446104 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1GAATDO2ALDH1A1
SCHEMBL8467667 0.79 TP53 (0.46) HSP90AA1HSP90AB1TP53GAAALDH1A1
SCHEMBL8465211 0.79 S100A4 (0.46) HSP90AA1HSP90AB1TP53GAATDO2
SCHEMBL8465123 0.79 S100A4 (0.46) HSP90AA1HSP90AB1TP53GAATDO2
SCHEMBL1274825 0.78 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed