SCHEMBL8465101

SCHEMBL8465101

Cc1ccc2nc3c(n2c1)C(=O)C(=O)c1ccccc1-3

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.50
HSP90AB1 P08238 1/20 0.50
NR1H4 Q96RI1 2/20 0.44
PARP1 P09874 1/20 0.43
RAB9A P51151 3/20 0.42
NPC1 O15118 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
MAPT P10636 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
PKM P14618 1/20 0.42
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
AKT1 P31749 1/20 0.42
AKT2 P31751 1/20 0.42
CYP11B1 P15538 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31237237 1.00 HSP90AA1 (0.50) HSP90AA1HSP90AB1NR1H4PARP1RAB9A
Sulfuric Acid SCHEMBL8465210 0.95 HSP90AA1 (0.46) HSP90AA1HSP90AB1NR1H4PARP1RAB9A
SCHEMBL8464925 0.90 HSP90AA1 (0.63) HSP90AA1HSP90AB1NR1H4PARP1RAB9A
SCHEMBL8468193 0.84 HSP90AA1 (0.51) HSP90AA1HSP90AB1PARP1RAB9ANPC1
SCHEMBL28557674 0.83 TDP2 (0.50) HSP90AA1HSP90AB1NR1H4RAB9ANPC1
SCHEMBL29846716 0.83 TDP2 (0.50) HSP90AA1HSP90AB1NR1H4RAB9ANPC1
SCHEMBL8466530 0.82 HSP90AA1 (0.50) HSP90AA1HSP90AB1RAB9ANPC1ALDH1A1
SCHEMBL8465416 0.82 HSP90AA1 (0.50) HSP90AA1HSP90AB1PARP1RAB9ANPC1
SCHEMBL8465216 0.78 HSP90AA1 (0.79) HSP90AA1HSP90AB1
SCHEMBL8465273 0.78 HSP90AA1 (0.52) HSP90AA1HSP90AB1PARP1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed