SCHEMBL8464925

SCHEMBL8464925

Cc1ccc2nc3c(n2c1)C(=O)c1ccccc1C3=O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.63
HSP90AB1 P08238 1/20 0.63
CYP1A2 P05177 2/20 0.49
CYP3A4 P08684 2/20 0.49
CYP2C19 P33261 2/20 0.49
NR1H4 Q96RI1 2/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
IDO1 P14902 2/20 0.44
TDO2 P48775 2/20 0.44
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
STAT3 P40763 1/20 0.44
KMT2A Q03164 1/20 0.44
PARP1 P09874 1/20 0.44
RAB9A P51151 3/20 0.43
MAPT P10636 3/20 0.43
NPC1 O15118 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465101 0.90 HSP90AA1 (0.50) HSP90AA1HSP90AB1NR1H4SMN1; SMN2ALDH1A1
SCHEMBL31237237 0.90 HSP90AA1 (0.50) HSP90AA1HSP90AB1NR1H4SMN1; SMN2ALDH1A1
Sulfuric Acid SCHEMBL8465210 0.85 HSP90AA1 (0.46) HSP90AA1HSP90AB1NR1H4SMN1; SMN2ALDH1A1
SCHEMBL8465227 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1CYP1A2CYP3A4CYP2C19
SCHEMBL13446104 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1CYP1A2CYP3A4CYP2C19
SCHEMBL8465390 0.82 HSP90AA1 (0.63) HSP90AA1HSP90AB1CYP1A2CYP3A4CYP2C19
SCHEMBL29846716 0.79 TDP2 (0.50) HSP90AA1HSP90AB1NR1H4SMN1; SMN2ALDH1A1
SCHEMBL28557674 0.79 TDP2 (0.50) HSP90AA1HSP90AB1NR1H4SMN1; SMN2ALDH1A1
SCHEMBL1274825 0.78 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1KDM4EHPGD
SCHEMBL8464965 0.77 HSP90AA1 (0.74) HSP90AA1HSP90AB1ALDH1A1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US claimed
US-5981544-A Mono-- or diketone tetracyclic derivatives and therapeutical uses thereof LABORATOIRE INNOTHERA (FR) 1999-11-09 US disclosed