Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465404 | 0.86 | HTR6 (0.51) | KCNN4KCNA3MAPTCYP26A1ALDH1A1 | |
| SCHEMBL8032740 | 0.82 | ALDH1A1 (0.39) | MMP2KCNN4KCNA3MAPTALDH1A1 | |
| SCHEMBL26308101 | 0.73 | ALDH1A1 (0.40) | MMP2KCNN4KCNA3MAPTALDH1A1 | |
| SCHEMBL25412364 | 0.72 | ALDH1A1 (0.40) | KCNN4KCNA3MAPTALDH1A1NLRP3 | |
| SCHEMBL25412368 | 0.72 | ALDH1A1 (0.40) | KCNN4KCNA3MAPTALDH1A1NLRP3 | |
| SCHEMBL25411871 | 0.71 | ALDH1A1 (0.39) | KCNN4KCNA3MAPTALDH1A1NLRP3 | |
| SCHEMBL25411864 | 0.71 | ALDH1A1 (0.39) | KCNN4KCNA3MAPTALDH1A1NLRP3 | |
| SCHEMBL28857559 | 0.71 | KCNN4 (0.52) | MMP2KCNN4KCNA3MAPTALDH1A1 | |
| SCHEMBL25411450 | 0.71 | ALDH1A1 (0.40) | MMP2KCNN4KCNA3MAPTALDH1A1 | |
| SCHEMBL25411441 | 0.71 | ALDH1A1 (0.40) | MMP2KCNN4KCNA3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |