Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | APP | P05067 | 6/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461410 | 0.86 | LOXL2 (0.47) | GFERAXLKMT2AMAPK1NPC1 | |
| Phosphine SCHEMBL9339078 | 0.84 | LOXL2 (0.46) | GFERAXLKMT2AMAPK1NPC1 | |
| SCHEMBL6630285 | 0.82 | NPC1 (0.63) | GFERAXLALDH1A1MAPTKDM4E | |
| SCHEMBL7222770 | 0.82 | GFER (0.56) | GFERAXLALDH1A1MAPTKDM4E | |
| SCHEMBL7547176 | 0.82 | GFER (0.56) | GFERAXLALDH1A1MAPTKDM4E | |
| SCHEMBL1729400 | 0.82 | GFER (0.61) | GFERAXLALDH1A1MAPTKDM4E | |
| SCHEMBL4390136 | 0.80 | NPC1 (0.53) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5968511 | 0.79 | GFER (0.57) | GFERAXLALDH1A1MAPTKDM4E | |
| SCHEMBL29184144 | 0.79 | RAB9A (0.47) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL26426430 | 0.79 | RAB9A (0.56) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| CN-1021823-C | Substituted chroman compounds for treatment of asthma, arthritis and the like | PFIZER (US) | 1993-08-18 | — | — | CN | disclosed |
| EP-0313295-B1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| CN-1064864-A | The tetraline that replaces and the preparation method of allied compound | PFIZER (US) | 1992-09-30 | — | — | CN | disclosed |
| CN-1063489-A | Substituted benzotetrahydropyridines and related compounds | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| CN-1032659-A | Substituted tetralins, chromans and like compounds for the treatment of asthma, arthritis and like diseases | PFIZER (US) | 1989-05-03 | — | — | CN | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |