SCHEMBL8465247

SCHEMBL8465247

C=C(C)C(=O)Nc1ccc(Nc2ccc(C)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.59
TDP1 Q9NUW8 2/20 0.57
NPC1 O15118 5/20 0.55
RAB9A P51151 5/20 0.55
KDM4E B2RXH2 2/20 0.55
POLB P06746 4/20 0.50
TGM2 P21980 1/20 0.50
MAPT P10636 4/20 0.47
PKM P14618 1/20 0.46
KIF11 P52732 1/20 0.46
HPGD P15428 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
ALDH1A1 P00352 1/20 0.45
HTT P42858 1/20 0.45
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL959539 0.94 RXFP1 (0.65) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL439393 0.86 RXFP1 (0.74) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL166821 0.85 MAPT (0.67) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL23966424 0.84 RXFP1 (0.54) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL11307388 0.82 RAB9A (0.54) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL17299114 0.81 RXFP1 (0.62) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL8465748 0.81 NPC1 (0.58) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL7784361 0.80 IDO1 (0.55) RXFP1RAB9AKDM4EPOLBMAPT
SCHEMBL17084525 0.80 RXFP1 (0.67) RXFP1TDP1NPC1RAB9AKDM4E
SCHEMBL4647437 0.80 TDP1 (0.87) TDP1NPC1RAB9AKDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025102500-A1 NITRILE RUBBER, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国石油天然气股份有限公司 2025-05-22 WO claimed
CN-119978235-A Nitrile rubber and preparation method and application thereof 中国石油天然气股份有限公司 2025-05-13 CN claimed
CN-119978233-A Preparation method of nitrile rubber with improved thermo-oxidative aging resistance 中国石油天然气股份有限公司 2025-05-13 CN claimed
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US claimed
US-4376846-A OIL AND OZONE RESISTANT AND HEAT AGING RESISTANT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-03-15 US claimed
WO-2025102500-A1 NITRILE RUBBER, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国石油天然气股份有限公司 2025-05-22 WO disclosed
CN-119978233-A Preparation method of nitrile rubber with improved thermo-oxidative aging resistance 中国石油天然气股份有限公司 2025-05-13 CN disclosed
CN-119978235-A Nitrile rubber and preparation method and application thereof 中国石油天然气股份有限公司 2025-05-13 CN disclosed
US-20090220877-A1 PHOTOCURABLE COMPOSITION, OVERPRINT, AND PRODUCTION PROCESS THEREFOR FUJIFILM CORPORATION (JP) 2009-09-03 US disclosed
US-5936038-A MIXTURE CONTAINING ELASTOMER HAVING PENDANT REACTIVE AMINE GROUP AND PHENOLIC RESIN CURATIVE THE UNIVERSITY OF AKRON (US) 1999-08-10 US disclosed
EP-0570825-B1 Tire sidewall composition containing silica having low PH GOODYEAR TIRE & RUBBER (US) 1996-08-07 EP disclosed
EP-0475215-B1 Carboxylic acid esters with thio groups GOODYEAR TIRE & RUBBER (US) 1994-10-19 EP disclosed
US-5244028-A Natural rubber or polybutadiene, silica, antidegradation agent, carbon black THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-09-14 US disclosed
US-5216049-A A phenolic or amine stabilizer and an organothioalkylene styrene bound to a polymer; aging resistance; rubbers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1993-06-01 US disclosed
EP-0475215-A1 Carboxylic acid esters with thio groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 1992-03-18 EP disclosed
US-5069819-A SYNERGISTS FOR CONVENTIONAL PHENOLIC AND AMINE ANTIOXIDANTS THE GOODYEAR TIRE & RUBBER COMPANY (US) 1991-12-03 US disclosed
EP-0028999-B1 PROCESS FOR THE PREPARATION OF ANTIOXIDANT AMIDES THE GOODYEAR TIRE & RUBBER COMPANY (US) 1983-03-23 EP disclosed
US-4376846-A OIL AND OZONE RESISTANT AND HEAT AGING RESISTANT JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1983-03-15 US disclosed
US-4286105-A AMIDATION THE GOODYEAR TIRE & RUBBER COMPANY (US) 1981-08-25 US disclosed
EP-0028999-A1 Process for the preparation of antioxidant amides THE GOODYEAR TIRE & RUBBER COMPANY (US) 1981-05-20 EP disclosed