Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1201256 | 0.84 | PDCD1 (0.31) | — | |
| SCHEMBL8903129 | 0.83 | PDCD1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL7646524 | 0.82 | PDCD1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL6056242 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL4556847 | 0.78 | KIF11 (0.35) | KDRDRD2CYP11B1CYP11B2KIF11 | |
| Hydrochloric Acid SCHEMBL8462241 | 0.78 | DRD2 (0.31) | DRD2KIF11PARP1PARP2JAK2 | |
| Hydrochloric Acid SCHEMBL8465331 | 0.78 | DRD2 (0.31) | DRD2CYP11B1CYP11B2KIF11PARP1 | |
| Hydrochloric Acid SCHEMBL4475556 | 0.78 | TOP1 (0.32) | DRD2KIF11PARP1PARP2JAK2 | |
| Hydrochloric Acid SCHEMBL8465421 | 0.78 | DRD2 (0.31) | DRD2KIF11PARP1PARP2JAK2 | |
| Hydrochloric Acid SCHEMBL2524020 | 0.77 | KIF11 (0.34) | KDRDRD2CYP11B1CYP11B2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859272-A | METALLOCENES; PRODUCES POLYOLEFINS HAVING A HIGH MELTING POINT AND A HIGH MOLECULAR WEIGHT; HIGH POLYMERIZATION ACTIVITY | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| US-5616663-A | TRANSITION METAL COMPOUND, ALUMINOXANE, COMPOUND WHICH REACTS WITH TRANSITION METAL COMPOUND TO FORM ION PAIR | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-01 | — | — | US | disclosed |