Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29754934 | 0.88 | KCNN4 (0.55) | MAOBMIFKCNN4KCNA3LMNA | |
| SCHEMBL28973132 | 0.88 | KCNN4 (0.55) | MAOBMIFKCNN4KCNA3LMNA | |
| SCHEMBL28973111 | 0.85 | KCNN4 (0.62) | MAOBMIFKCNN4KCNA3LMNA | |
| SCHEMBL29754844 | 0.85 | KCNN4 (0.62) | MAOBMIFKCNN4KCNA3LMNA | |
| SCHEMBL8465676 | 0.81 | LMNA (0.42) | KCNN4KCNA3LMNAALDH1A1KDM4E | |
| SCHEMBL8032658 | 0.80 | LMNA (0.45) | KCNN4KCNA3LMNAALDH1A1KDM4E | |
| SCHEMBL30274382 | 0.79 | MAPT (0.52) | MIFLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8465684 | 0.78 | LMNA (0.43) | KCNN4KCNA3LMNAALDH1A1KDM4E | |
| SCHEMBL28973113 | 0.77 | KCNN4 (0.57) | MIFKCNN4KCNA3LMNAMMP2 | |
| SCHEMBL29754973 | 0.77 | KCNN4 (0.57) | MIFKCNN4KCNA3LMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |