Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLEC | Q15149 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032662 | 1.00 | LMNA (0.45) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8465682 | 0.80 | MAOB (0.51) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8465684 | 0.78 | LMNA (0.43) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8465676 | 0.76 | LMNA (0.42) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8029313 | 0.75 | HTR6 (0.47) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8466244 | 0.72 | KMT2A (0.53) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30274382 | 0.72 | MAPT (0.52) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29754934 | 0.71 | KCNN4 (0.55) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL28973132 | 0.71 | KCNN4 (0.55) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL2703634 | 0.69 | KMT2A (0.47) | LMNAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166031-A | Substituted tetralins, chromans and related compounds in the treatment of asthma | PFIZER INC, (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1989003681-A1 | SUBSTITUTED TETRALINS, CHROMANS AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |