Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.42 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465614 | 0.82 | LOXL2 (0.43) | MRGPRX4RAB9ASMN1; SMN2 | |
| SCHEMBL8465579 | 0.82 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL8465588 | 0.82 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL8465586 | 0.82 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL8465734 | 0.82 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL8462737 | 0.72 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2 | |
| SCHEMBL8462745 | 0.72 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2 | |
| SCHEMBL8462733 | 0.72 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2 | |
| SCHEMBL8464461 | 0.71 | LTB4R (0.69) | CYSLTR1CYSLTR2 | |
| SCHEMBL8524172 | 0.71 | LTB4R (0.69) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998451-A | LIPOXYGENASE INHIBITORS | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
| US-5059609-A | Lipoxygenase inhibitors; leukotriene receptor blockers; psoriasis; antiulcer agents and myocardial infarctions | PFIZER INC. (US) | 1991-10-22 | — | — | US | disclosed |
| EP-0313295-A2 | Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1989-04-26 | — | — | EP | disclosed |