SCHEMBL8466237

SCHEMBL8466237

N#Cc1c(Oc2ccc(C(=O)c3ccc(N)cc3)cc2)cccc1Oc1ccc(C(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 4/20 0.46
PARP15 Q460N3 2/20 0.42
PARP2 Q9UGN5 2/20 0.42
SRD5A2 P31213 1/20 0.41
ALDH1A1 P00352 5/20 0.41
LMNA P02545 4/20 0.41
NPSR1 Q6W5P4 3/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 2/20 0.41
HPGD P15428 1/20 0.41
SCN9A Q15858 1/20 0.40
MAPK14 Q16539 1/20 0.40
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
HTT P42858 1/20 0.39
TNKS O95271 1/20 0.39
PARP14 Q460N5 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7192577 0.87 NCOA1 (0.49) ALDH1A1MAPTKDM4EHPGDNCOA1
SCHEMBL8462720 0.86 ALDH1A1 (0.52) ALDH1A1MAPTKDM4EHPGDNCOA1
SCHEMBL17085522 0.86 NCOA1 (0.47) ALDH1A1MAPTKDM4EHPGDNCOA1
SCHEMBL30777312 0.86 NCOA1 (0.47) ALDH1A1MAPTKDM4EHPGDNCOA1
SCHEMBL14264190 0.82 MAPT (0.55) PARP10PARP15PARP2SRD5A2LMNA
SCHEMBL28253414 0.81 LPAR1 (0.52) PARP10PARP15PARP2SRD5A2MAPT
SCHEMBL14264193 0.81 TLR8 (0.55) PARP10PARP15PARP2SRD5A2LMNA
SCHEMBL31456559 0.78 SMN1; SMN2 (0.53) ALDH1A1MAPTKDM4EHPGDMAPK14
SCHEMBL5012743 0.78 SMN1; SMN2 (0.53) ALDH1A1MAPTKDM4EHPGDMAPK14
SCHEMBL1362882 0.78 SMN1; SMN2 (0.53) ALDH1A1MAPTKDM4EHPGDMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659802-B1 Polyimide MITSUI CHEMICALS INC (JP) 1999-03-17 EP disclosed
US-5631377-A LONG-CHAIN AROMATIC DIAMINE MONOMER; MELT PROCESSABILITY, HEAT RESISTANCE MITSUI TOATSU CHEMICALS, INC. (JP) 1997-05-20 US disclosed
US-5508377-A IMPROVED PROCESSABILITY, HEAT RESISTANCE; ELECTRONICS, STRUCTURAL MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-04-16 US disclosed
EP-0639621-A2 Polyimide-based resin composition MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-02-22 EP disclosed