SCHEMBL8466351

SCHEMBL8466351

CCC(O[SiH3])(c1ccccc1)C1CCCCC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 10/20 0.43
CHRM1 P11229 10/20 0.43
KCNH2 Q12809 6/20 0.43
CYP2D6 P10635 5/20 0.43
CHRM3 P20309 7/20 0.40
CHRM4 P08173 6/20 0.40
SLC6A3 Q01959 2/20 0.40
KEAP1 Q14145 1/20 0.39
NFE2L2 Q16236 1/20 0.39
POLB P06746 1/20 0.39
CYP3A4 P08684 2/20 0.38
NFKB1 P19838 2/20 0.38
CHRM5 P08912 2/20 0.38
OPRM1 P35372 2/20 0.38
SIGMAR1 Q99720 2/20 0.38
GRIN2D O15399 1/20 0.38
GRIN3B O60391 1/20 0.38
HRH1 P35367 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2A Q12879 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25454417 0.76 CHRM3 (0.48) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL1313892 0.75 KEAP1 (0.46) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL1315214 0.74 KEAP1 (0.44) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL16191123 0.73 CHRM2 (0.48) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL4999770 0.72 KEAP1 (0.46) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL2933098 0.71 CHRM2 (0.66) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL12441787 0.71 CHRM2 (0.66) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL10379526 0.71 NFE2L2 (0.41) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL1313865 0.70 CHRM2 (0.47) CHRM2CHRM1KCNH2CYP2D6CHRM3
SCHEMBL1314097 0.70 CHRM2 (0.43) CHRM2CHRM1KCNH2CYP2D6CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787155-B1 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEM CO (US) 1999-06-09 EP disclosed
EP-0787155-A2 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEMICAL COMPANY (US) 1997-08-06 EP disclosed
US-5521263-A Catalysts and synthesis of high molecular weight amorphous polyolefins and recovery thereof EASTMAN CHEMICAL COMPANY (US) 1996-05-28 US disclosed
WO-1996011963-A2 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEMICAL COMPANY (US) 1996-04-25 WO disclosed
US-5414063-A Using solid magnesium chloride supported titanium tetrachloride catalyst component containing electron donor in combination with silicon compound and organoaluminum compound HUNTSMAN POLYPROPYLENE CORPORATION (US) 1995-05-09 US disclosed
EP-0459009-B1 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO LTD (JP) 1994-12-07 EP disclosed
EP-0322798-B1 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO LTD (JP) 1994-03-02 EP disclosed
US-5130284-A Coordination catalyst of magnesium, titanium and phthaloyl dichloride in alkylbenzenes TOHO TITANIUM CO., LTD. (JP) 1992-07-14 US disclosed
EP-0459009-A2 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO. LTD. (JP) 1991-12-04 EP disclosed
US-4970186-A DIETHOXYMAGNESIUM, PHTHALOYL CHLORIDE AND TITANIUM TETRA-CHLORIDE REACTION PRODUCT; STEREOSPECIFIC TOHO TITANIUM CO., LTD. (JP) 1990-11-13 US disclosed