SCHEMBL8466353

SCHEMBL8466353

CC[Si](OC)(c1ccccc1)C1CCCCC1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
RAB9A P51151 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
SLC6A2 P23975 2/20 0.33
SLC6A4 P31645 2/20 0.33
KDM4E B2RXH2 2/20 0.33
USP2 O75604 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
POLB P06746 1/20 0.32
ELANE P08246 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
TSHR P16473 1/20 0.31
GAA P10253 1/20 0.31
ALOX15 P16050 1/20 0.31
PKM P14618 1/20 0.31
CTDSP1 Q9GZU7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1315215 0.77 SLC6A2 (0.36) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL11192108 0.75 L3MBTL1 (0.40) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL301957 0.75 SLC6A2 (0.36) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL1313895 0.75 SLC6A2 (0.36) ALDH1A1RAB9ASLC6A2SLC6A4KDM4E
SCHEMBL4999771 0.74 SLC6A2 (0.34) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL22977552 0.74 ALDH1A1 (0.36) ALDH1A1RAB9ASLC6A2SLC6A4KDM4E
SCHEMBL9841261 0.73 MEN1 (0.30) MEN1KMT2A
SCHEMBL301913 0.73 SLC6A2 (0.33) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL5005517 0.72 L3MBTL1 (0.35) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4
SCHEMBL1313863 0.72 L3MBTL1 (0.35) ALDH1A1RAB9AL3MBTL1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787155-B1 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEM CO (US) 1999-06-09 EP disclosed
EP-0787155-A2 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEMICAL COMPANY (US) 1997-08-06 EP disclosed
US-5521263-A Catalysts and synthesis of high molecular weight amorphous polyolefins and recovery thereof EASTMAN CHEMICAL COMPANY (US) 1996-05-28 US disclosed
WO-1996011963-A2 CATALYSTS AND SYNTHESIS OF HIGH MOLECULAR WEIGHT AMORPHOUS POLYOLEFINS AND RECOVERY THEREOF EASTMAN CHEMICAL COMPANY (US) 1996-04-25 WO disclosed
US-5414063-A Using solid magnesium chloride supported titanium tetrachloride catalyst component containing electron donor in combination with silicon compound and organoaluminum compound HUNTSMAN POLYPROPYLENE CORPORATION (US) 1995-05-09 US disclosed
EP-0459009-B1 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO LTD (JP) 1994-12-07 EP disclosed
EP-0322798-B1 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO LTD (JP) 1994-03-02 EP disclosed
US-5130284-A Coordination catalyst of magnesium, titanium and phthaloyl dichloride in alkylbenzenes TOHO TITANIUM CO., LTD. (JP) 1992-07-14 US disclosed
EP-0459009-A2 A solid catalyst component for the polymerization of olefins and an olefin polymerization catalyst TOHO TITANIUM CO. LTD. (JP) 1991-12-04 EP disclosed
US-4970186-A DIETHOXYMAGNESIUM, PHTHALOYL CHLORIDE AND TITANIUM TETRA-CHLORIDE REACTION PRODUCT; STEREOSPECIFIC TOHO TITANIUM CO., LTD. (JP) 1990-11-13 US disclosed