Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | NPC1 | O15118 | 9/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846076 | 0.81 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL846721 | 0.81 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL847375 | 0.76 | TRPV1 (0.58) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL19392500 | 0.76 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL847374 | 0.75 | NAMPT (0.45) | RAB9ANPC1HTR2CMCHR1POLB | |
| SCHEMBL18470910 | 0.75 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL3142490 | 0.75 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL846391 | 0.72 | SMN1; SMN2 (0.55) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL846284 | 0.71 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2TP53MAPK1 | |
| SCHEMBL846074 | 0.71 | KDR (0.67) | RAB9ANPC1SMN1; SMN2TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |