Treosulfan

Treosulfan

SCHEMBL8466701

CS(=O)(=O)OC[C@@H](O)[C@H](O)COS(C)(=O)=O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.43
ALDH1A1 P00352 2/20 0.43
TSHR P16473 2/20 0.43
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
MMP9 P14780 1/20 0.43
ALOX15 P16050 1/20 0.43
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Treosulfan SCHEMBL5399430 1.00 USP2 (0.43) USP2ALDH1A1TSHRKDM4ELMNA
Treosulfan SCHEMBL8142 1.00 USP2 (0.43) USP2ALDH1A1TSHRKDM4ELMNA
SCHEMBL9359843 0.91 LMNA (0.37) USP2ALDH1A1TSHRKDM4ELMNA
SCHEMBL9359906 0.91 LMNA (0.37) USP2ALDH1A1TSHRKDM4ELMNA
SCHEMBL4951404 0.90 ALDH1A1 (0.40) USP2ALDH1A1TSHRKDM4ELMNA
Treosulfan SCHEMBL28276683 0.89 KDM4E (0.36) USP2ALDH1A1TSHRKDM4ELMNA
Treosulfan SCHEMBL28142583 0.89 KDM4E (0.36) USP2ALDH1A1TSHRKDM4ELMNA
Treosulfan SCHEMBL28086148 0.89 TSHR (0.65) USP2ALDH1A1TSHRKDM4ELMNA
SCHEMBL7621803 0.87 CA1 (0.39) USP2ALDH1A1TSHRKDM4ELMNA
SCHEMBL21815666 0.87 ALDH1A1 (0.39) USP2ALDH1A1TSHRKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11349558-A None JP disclosed
JP-H11349558-A PRODUCTION OF 1,4-BIS(ORGANIC SULFONYLOXY)-2,3-BUTANEDIOL MITSUBISHI CHEMICAL CORP 1999-12-21 JP disclosed
EP-0586378-B1 NOVEL PLATINUM(II) COMPLEX AND PROCESSES FOR PREPARING THE SAME SUNKYONG IND LTD (KR) 1998-09-23 EP disclosed
US-5395947-A Antitumor agents SUNKYONG INDUSTRIES, LTD. (KR) 1995-03-07 US disclosed
EP-0586378-A1 NOVEL PLATINUM(II) COMPLEX AND PROCESSES FOR PREPARING THE SAME SUNKYONG INDUSTRIES LTD. (KR) 1994-03-16 EP disclosed
WO-1992016539-A1 NOVEL PLATINUM(II) COMPLEX AND PROCESSES FOR PREPARING THE SAME SUNKYONG INDUSTRIES LTD. (KR) 1992-10-01 WO disclosed