SCHEMBL8467150

SCHEMBL8467150

CC(c1ccccc1C(C)P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
GABRA1 P14867 2/20 0.36
GABRB2 P47870 2/20 0.36
ESR1 P03372 4/20 0.33
ESR2 Q92731 4/20 0.33
TSHR P16473 2/20 0.32
SLC6A2 P23975 3/20 0.32
FAAH O00519 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
HPGD P15428 1/20 0.32
GABRB1 P18505 1/20 0.32
GABRG2 P18507 1/20 0.32
PTGS1 P23219 1/20 0.32
HTR2C P28335 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5454194 0.85 CYP3A4 (0.32) CYP3A4TDP1GABRA1GABRB2
SCHEMBL27908650 0.85 GABRA1 (0.54) CYP3A4TDP1GABRA1GABRB2ESR1
SCHEMBL3963448 0.83 CYP3A4 (0.41) CYP3A4TDP1ESR1ESR2
SCHEMBL27504866 0.82 ADRA2A (0.39) CYP3A4TDP1ESR1TSHRSLC6A2
SCHEMBL7059781 0.82 ALDH1A1 (0.47) CYP1A2CYP2C9SLC6A4CYP2A6
SCHEMBL27925139 0.80 DPP4 (0.37) SLC6A2TAAR1MAOASLC6A4SLC6A3
SCHEMBL27991666 0.80 CD44 (0.36) CYP3A4TSHRSLC6A2TAAR1MAOA
SCHEMBL7781865 0.80 TAAR1 (0.39) CYP3A4TDP1TSHRLMNAHIF1A
SCHEMBL5107698 0.80 TAAR1 (0.39) CYP3A4TDP1TSHRLMNAHIF1A
SCHEMBL2880133 0.79 CYP3A4 (0.30) CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0627439-B1 Hydroformylation process using novel phosphine-rhodium catalyst system EASTMAN CHEM CO (US) 1999-07-21 EP disclosed
EP-0627439-A1 Hydroformylation process using novel phosphine-rhodium catalyst system EASTMAN CHEMICAL COMPANY (US) 1994-12-07 EP disclosed
US-5344988-A Hydroformylation process using novel phosphine-rhodium catalyst system EASTMAN CHEMICAL COMPANY (US) 1994-09-06 US disclosed
US-5332846-A Hydroformylation process using novel phosphine-rhodium catalyst system EASTMAN KODAK COMPANY (US) 1994-07-26 US disclosed