SCHEMBL8467458

SCHEMBL8467458

CCCN(C(=O)n1nnn(-c2ccccc2Br)c1=O)C1CCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
P2RX1 P51575 2/20 0.36
P2RX4 Q99571 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.34
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
SLC5A1 P13866 1/20 0.34
SLC5A2 P31639 1/20 0.34
DRD2 P14416 1/20 0.33
DRD3 P35462 1/20 0.33
SLC16A3 O15427 1/20 0.33
SLC16A1 P53985 1/20 0.33
ALDH1A1 P00352 1/20 0.33
ALOX15 P16050 1/20 0.33
SLC6A4 P31645 2/20 0.33
KCNH2 Q12809 1/20 0.33
TRPV1 Q8NER1 1/20 0.32
SLC6A2 P23975 1/20 0.32
TSHR P16473 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8467455 1.00 LMNA (0.39) LMNAP2RX1P2RX4L3MBTL1KMT2A
SCHEMBL8464239 0.92 LMNA (0.44) LMNAL3MBTL1KMT2AMEN1SLC5A1
SCHEMBL8464241 0.92 LMNA (0.44) LMNAL3MBTL1KMT2AMEN1SLC5A1
SCHEMBL8163289 0.91 LMNA (0.46) LMNAL3MBTL1KMT2AMEN1ALDH1A1
SCHEMBL8163291 0.91 LMNA (0.46) LMNAL3MBTL1KMT2AMEN1ALDH1A1
SCHEMBL8466641 0.88 DRD2 (0.41) P2RX1P2RX4L3MBTL1KMT2AMEN1
SCHEMBL8464533 0.88 DRD2 (0.41) P2RX1P2RX4L3MBTL1KMT2AMEN1
SCHEMBL12115702 0.87 DRD2 (0.42) P2RX1P2RX4L3MBTL1KMT2AMEN1
SCHEMBL8466659 0.85 LMNA (0.35) LMNAL3MBTL1KMT2AMEN1DRD2
SCHEMBL8466663 0.85 LMNA (0.35) LMNAL3MBTL1KMT2AMEN1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714602-B1 Sulphonylaminophenyluracil herbicides for paddy field BAYER AGROCHEM KK (JP) 1999-05-12 EP claimed
US-5641725-A Sulphonylaminophenyluracil herbicides for paddy field NIHON BAYER AGROCHEM K.K. (JP) 1997-06-24 US claimed
EP-0714602-A1 Sulphonylaminophenyluracil herbicides for paddy field NIHON BAYER AGROCHEM K.K. (JP) 1996-06-05 EP claimed
EP-0714602-B1 Sulphonylaminophenyluracil herbicides for paddy field BAYER AGROCHEM KK (JP) 1999-05-12 EP disclosed
US-5833733-A SOLID CORE, COATING; FUNGICIDE, HERBICIDE, NUTRIENTS; FOR RICE PADDYS NIHON BAYER AGROCHEM K.K. (JP) 1998-11-10 US disclosed
US-5641725-A Sulphonylaminophenyluracil herbicides for paddy field NIHON BAYER AGROCHEM K.K. (JP) 1997-06-24 US disclosed
US-5635446-A Herbicidal tetrazolinones combined with other herbicides NIRON BAYER AGROCHEM K.K. (JP) 1997-06-03 US disclosed
US-5541336-A Herbicidal tetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1996-07-30 US disclosed
EP-0714602-A1 Sulphonylaminophenyluracil herbicides for paddy field NIHON BAYER AGROCHEM K.K. (JP) 1996-06-05 EP disclosed
EP-0672663-A1 Herbicidal tetrazolinones NIHON BAYER AGROCHEM K.K. (JP) 1995-09-20 EP disclosed