Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757183 | 0.77 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL12323193 | 0.76 | HDAC8 (0.67) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL7056987 | 0.76 | HDAC8 (0.67) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL7640270 | 0.75 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL16166996 | 0.75 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL8674851 | 0.75 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL5965284 | 0.75 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL7177409 | 0.75 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL3077769 | 0.74 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL5140992 | 0.74 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892816-A1 | POLYMERIZATION PROCESS FOR PRODUCING POLYOLEFIN ELASTOMER, CATION-GENERATING COCATALYST FOR ACTIVATING A METALLOCENE PROCATALYST, POLYOLEFIN ELASTOMER POSSESSING A UNIQUE COMBINATION OF PROPERTIES AND PRODUCTS MANUFACTURED THEREFROM | UNIROYAL CHEMICAL COMPANY, Inc. (US) | 1999-01-27 | — | — | EP | disclosed |
| US-5723560-A | GROUP 4 OR 5 METAL CATALYST FOR OLEFIN POLYMERIZATION | EXXON CHEMICAL PATENTS INC. (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1997038019-A1 | POLYMERIZATION PROCESS FOR PRODUCING POLYOLEFIN ELASTOMER, CATION-GENERATING COCATALYST FOR ACTIVATING A METALLOCENE PROCATALYST, POLYOLEFIN ELASTOMER POSSESSING A UNIQUE COMBINATION OF PROPERTIES AND PRODUCTS MANUFACTURED THEREFROM | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1997-10-16 | — | — | WO | disclosed |
| EP-0705283-A1 | PROCESS FOR PRODUCING AMORPHOUS POLY-$g(a)-OLEFINS WITH A MONOCYCLOPENTADIENYL TRANSITION METAL CATALYST SYSTEM | EXXON CHEMICAL PATENTS INC. (US) | 1996-04-10 | — | — | EP | disclosed |
| US-5504169-A | FORMING HIGH MOLECULAR WEIGHT POLYPROPYLENE BY CATALYZING IN PRESENCE OF AN ACTIVATOR AND A TITANIUM CYCLOPENTADIENYL COMPLEXES | EXXON CHEMICAL PATENTS INC. (US) | 1996-04-02 | — | — | US | disclosed |
| US-5420217-A | Polymerization catalyst and promoter | EXXON CHEMICAL PATENTS INC. (US) | 1995-05-30 | — | — | US | disclosed |
| WO-1995000562-A1 | PROCESS FOR PRODUCING AMORPHOUS POLY-α-OLEFINS WITH A MONOCYCLOPENTADIENYL TRANSITION METAL CATALYST SYSTEM | EXXON CHEMICAL PATENTS INC. (US) | 1995-01-05 | — | — | WO | disclosed |