Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12323193 | 0.78 | HDAC8 (0.67) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL7056987 | 0.78 | HDAC8 (0.67) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL8467658 | 0.77 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL14050751 | 0.76 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL28376355 | 0.76 | HDAC8 (0.64) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL18513474 | 0.76 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL18513475 | 0.76 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL3077769 | 0.76 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL5140992 | 0.76 | HDAC6 (1.00) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL23192018 | 0.74 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891049-B1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI SA (FR) | 2017-07-19 | — | — | EP | disclosed |
| EP-2240179-B1 | IMIDAZOPYRIDAZINE AS PAR1 INHIBITORS, THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINE | SANOFI SA (FR) | 2016-08-17 | — | — | EP | disclosed |
| EP-2226319-B1 | Process for the preparation of 2-(2-aminopyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |
| EP-1937673-B1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI SA (FR) | 2015-10-21 | — | — | EP | disclosed |
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2240486-B1 | TRIAZOLIUM SALTS AS PAR1 INHIBITORS, THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINE | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-1841772-B1 | TETRAHYDROFURANE DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI SA (FR) | 2015-05-06 | — | — | EP | disclosed |
| EP-2558465-B1 | TRICYCLIC PYRIDYL-VINYL-PYROLES AS PAR1 INHIBITORS | SANOFI SA (FR) | 2014-12-17 | — | — | EP | disclosed |
| EP-2558462-B1 | Pyridyl-vinyl-pyrazolo-chinolines as PAR1 inhibitors | SANOFI SA (FR) | 2014-10-22 | — | — | EP | disclosed |
| EP-2300462-B1 | MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI SA (FR) | 2014-05-21 | — | — | EP | disclosed |
| EP-0861236-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997018194-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED α-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-22 | — | — | WO | disclosed |
| EP-0764637-A2 | 2-Cyano-3-mercaptocrotonamides | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-26 | — | — | EP | disclosed |
| EP-0749429-A1 | 3,5-DISUBSTITUTED AND 3,5,6-TRISUBSTITUTED 2-ISOXAZOLINES AND ISOXAZOLES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-27 | — | — | EP | disclosed |
| EP-0703239-A1 | Aminomethylphosphonic and aminomethylphosphinic acids derivatives and their use in the treatment of degenerative articular diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-03-27 | — | — | EP | disclosed |
| WO-1995024397-A1 | 3,5-DISUBSTITUTED AND 3,5,6-TRISUBSTITUTED 2-ISOXAZOLINES AND ISOXAZOLES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-14 | — | — | WO | disclosed |
| EP-0313997-B1 | Medicine, therein contained phosphor containing 2-isoxazolidines and isoxazoles, as well as process for preparing those heterocyclic compounds | HOECHST AG (DE) | 1994-03-09 | — | — | EP | disclosed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |
| EP-0313997-A2 | Medicine, therein contained phosphor containing 2-isoxazolidines and isoxazoles, as well as process for preparing those heterocyclic compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-03 | — | — | EP | disclosed |
| EP-0276805-A2 | Substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |