Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TTBK1 | Q5TCY1 | 11/20 | 0.57 |
| ▸ | TTBK2 | Q6IQ55 | 11/20 | 0.57 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828413 | 0.98 | S1PR2 (0.59) | S1PR2LMNASMN1; SMN2NPSR1TTBK1 | |
| Nonapyrimine SCHEMBL29385365 | 0.98 | S1PR2 (0.59) | S1PR2LMNASMN1; SMN2NPSR1TTBK1 | |
| Nonapyrimine SCHEMBL2110854 | 0.98 | S1PR2 (0.59) | S1PR2LMNASMN1; SMN2NPSR1TTBK1 | |
| SCHEMBL16266363 | 0.89 | TTBK1 (0.61) | TTBK1TTBK2BTKTNNI3KALDH1A1 | |
| SCHEMBL16266428 | 0.82 | LMNA (0.56) | LMNASMN1; SMN2TTBK1TTBK2BTK | |
| SCHEMBL27545719 | 0.82 | TTBK1 (0.54) | TTBK1TTBK2BTKHDAC6 | |
| SCHEMBL22909512 | 0.82 | TTBK1 (0.57) | TTBK1TTBK2BTKTNNI3KHDAC6 | |
| SCHEMBL23409028 | 0.81 | TTBK1 (0.59) | TTBK1TTBK2BTKTNNI3KHDAC6 | |
| SCHEMBL30485458 | 0.81 | TTBK1 (0.62) | TTBK1TTBK2BTKHDAC6 | |
| SCHEMBL23409027 | 0.81 | TTBK1 (0.62) | TTBK1TTBK2BTKHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017803-A9 | ADENOSINE KINASE INHIBITORS | — | 1994-09-29 | — | — | WO | disclosed |
| WO-1994017803-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |
| EP-0496617-A1 | Adenosine kinase inhibitors | GENSIA, INC. (US) | 1992-07-29 | — | — | EP | disclosed |