Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 7/20 | 0.50 |
| ▸ | RARB | P10826 | 7/20 | 0.50 |
| ▸ | RARA | P10276 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7691901 | 0.82 | RARB (0.64) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL9125988 | 0.74 | RARB (0.64) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL16088611 | 0.74 | KMT2A (0.58) | GAAL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL7821783 | 0.74 | MAPT (0.74) | GAAL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL7155475 | 0.73 | RARB (0.67) | RARGRARBRARARXRAALDH1A1 | |
| SCHEMBL9446451 | 0.73 | RARA (0.60) | RARGRARBRARAL3MBTL1ALDH1A1 | |
| SCHEMBL2699444 | 0.73 | HTT (0.69) | GAAL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL5441235 | 0.72 | RARA (0.51) | RARGRARBRARAGAAALDH1A1 | |
| SCHEMBL16127868 | 0.72 | CREBBP (0.64) | GAAL3MBTL1ALDH1A1KMT2APRNP | |
| SCHEMBL7698741 | 0.71 | RARA (0.48) | RARGRARBRARAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856490-A | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity | ALLERGAN (US) | 1999-01-05 | — | — | US | disclosed |