Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 15/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840882 | 0.81 | CYP19A1 (0.46) | CYP19A1MAOBHDAC1PKMTSHR | |
| SCHEMBL8470357 | 0.81 | CYP19A1 (0.52) | CYP19A1MAOB | |
| SCHEMBL3520052 | 0.81 | CYP19A1 (0.58) | CYP19A1MAOBPKMTSHRSIGMAR1 | |
| SCHEMBL11635929 | 0.80 | CYP19A1 (0.53) | CYP19A1MAOBPKMTSHRSIGMAR1 | |
| SCHEMBL11424192 | 0.78 | CYP19A1 (0.48) | CYP19A1MAOBPKMTSHRSIGMAR1 | |
| Fluoride SCHEMBL11424190 | 0.77 | CYP19A1 (0.50) | CYP19A1MAOBPKMTSHRSIGMAR1 | |
| SCHEMBL8470385 | 0.77 | CYP19A1 (0.47) | CYP19A1MAOBHDAC1PKMTSHR | |
| SCHEMBL31336705 | 0.74 | CYP19A1 (0.54) | CYP19A1MAOBPKMTSHRSIGMAR1 | |
| SCHEMBL9832882 | 0.74 | MAOB (0.47) | CYP19A1MAOBHDAC1SIGMAR1 | |
| SCHEMBL28699476 | 0.73 | KDM4E (0.51) | CYP19A1HDAC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886016-A | ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5670532-A | Pyrazolyl derivatives for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5565482-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5547975-A | ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 1996-08-20 | — | — | US | disclosed |
| WO-1996009304-A1 | BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-28 | — | — | WO | disclosed |