SCHEMBL28699476

SCHEMBL28699476

O=C1c2ccccc2CC1C(=O)C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
MAPT P10636 1/20 0.51
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ACHE P22303 6/20 0.47
SMN1; SMN2 Q16637 1/20 0.41
METAP1 P53582 4/20 0.41
ALDH1A1 P00352 1/20 0.39
HBB P68871 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CYP19A1 P11511 1/20 0.38
TSHR P16473 1/20 0.37
HDAC1 Q13547 1/20 0.36
LMNA P02545 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6352009 0.84 ACHE (0.47) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL29365032 0.84 ACHE (0.47) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL19836626 0.83 ALDH1A1 (0.54) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL30702212 0.79 MAPT (0.56) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL3948845 0.79 MAPT (0.56) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL5311960 0.77 KMT2A (0.55) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL856747 0.77 ACHE (0.56) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL28207369 0.77 MAPT (0.51) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL23618751 0.76 MAPT (0.70) KDM4EMEN1MAPTKMT2AL3MBTL1
SCHEMBL9257883 0.75 CYP19A1 (0.42) KDM4EMEN1MAPTKMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024085332-A1 ANTIBODY-BOUND METAL-ORGANIC FRAMEWORK AND ANTICANCER COMPOSITION COMPRISING SAME 울산과학기술원 2024-04-25 WO claimed
US-20260104418-A1 CLAUDIN18 ANTIBODIES AND METHODS OF TREATING CANCER UNIV CALIFORNIA (US) 2026-04-16 US disclosed
US-20250333501-A1 CLAUDIN 4 AND CLAUDIN 9 ANTIBODIES AND METHODS OF TREATING CANCER UNIV CALIFORNIA (US) 2025-10-30 US disclosed
US-20250282870-A1 CTLA4-BINDING PROTEINS AND METHODS OF TREATING CANCER BIOENTRE LLC (US) 2025-09-11 US disclosed
US-20250228955-A1 PLATFORM TECHNOLOGY FOR BISPECIFIC ANTIGENBINDING PROTEINS ALBERT EINSTEIN COLLEGE OF MEDICINE (US) 2025-07-17 US disclosed
EP-3458477-B1 ANTI-FACTOR IX PADUA ANTIBODIES TAKEDA PHARMACEUTICALS CO (JP) 2025-07-09 EP disclosed
US-12345709-B2 CLAUDIN18 antibodies and methods of treating cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-07-01 US disclosed
US-12269900-B2 Inhibitors of β integrin-G protein α subunit binding interactions THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2025-04-08 US disclosed
EP-4527408-A2 CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES The Regents of the University of California (US) 2025-03-26 EP disclosed
CN-119592693-A Application of Circ2977 as colorectal cancer diagnosis marker and treatment target 重庆医科大学国际体外诊断研究院 2025-03-11 CN disclosed
WO-2022125967-A2 COMBINATION THERAPIES FOR THE TREATMENT OF CANCER ERASCA, INC. (US) 2022-06-16 WO disclosed
US-20220177583-A1 CLAUDIN-6 BISPECIFIC ANTIBODIES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-06-09 US disclosed
US-20220160872-A1 Drug Adsorbed Highly Porous Activated Carbon for Enhanced Drug Delivery THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2022-05-26 US disclosed
US-20220162299-A1 CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-05-26 US disclosed
EP-3999548-A1 CLAUDIN18 ANTIBODIES AND METHODS OF TREATING CANCER The Regents of the University of California (US) 2022-05-25 EP disclosed
WO-2022081773-A1 METHODS OF TREATING HERPES VIRAL INFECTION WITH 4-PHENYLBUTYRATE (PBA) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2022-04-21 WO disclosed
WO-2022076529-A1 METHODS FOR X CHROMOSOME REACTIVATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-04-14 WO disclosed
EP-3956663-A1 A METHOD OF PROFILING THE ENERGETIC METABOLISM OF A POPULATION OF CELLS Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2022-02-23 EP disclosed
EP-3952841-A1 DRUG ADSORBED HIGHLY POROUS ACTIVATED CARBON FOR ENHANCED DRUG DELIVERY THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2022-02-16 EP disclosed
CN-113981243-A Method for extracting and separating lithium and alkaline earth metal from salt lake brine with high sodium-lithium ratio 中国科学院青海盐湖研究所 2022-01-28 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260104418-A1 CLAUDIN18 ANTIBODIES AND METHODS OF TREATING CANCER EPCAM, IGSF11, EPB41L2 KDM4E 1155/4885MEN1 2600/4885MAPT 1819/4885
US-20220162299-A1 CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES EPCAM, LY96, CD2BP2 KDM4E 3852/4885MEN1 4141/4885MAPT 2024/4885
US-20220177583-A1 CLAUDIN-6 BISPECIFIC ANTIBODIES EPCAM, CD2BP2, LY96 KDM4E 4130/4885MEN1 3768/4885MAPT 2576/4885
US-20250228955-A1 PLATFORM TECHNOLOGY FOR BISPECIFIC ANTIGENBINDING PROTEINS CD2BP2, CD2, DBNL KDM4E 3691/4885MEN1 3223/4885MAPT 2266/4885
US-12345709-B2 CLAUDIN18 antibodies and methods of treating cancer EPCAM, ICAM1, VCAM1 KDM4E 4279/4885MEN1 2014/4885MAPT 2817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.