SCHEMBL84708

SCHEMBL84708

O=C1COC(c2ccccc2)=N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
MAOB P27338 2/20 0.41
NPC1 O15118 3/20 0.40
RAB9A P51151 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPT P10636 4/20 0.39
ALDH1A1 P00352 4/20 0.39
GAA P10253 3/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 2/20 0.39
HPGD P15428 1/20 0.38
GFER P55789 1/20 0.38
HSD17B10 Q99714 1/20 0.38
MEN1 O00255 2/20 0.38
PTGS1 P23219 3/20 0.37
PTGS2 P35354 3/20 0.37
ABCB11 O95342 1/20 0.37
MT-CO2 P00403 1/20 0.37
HTR1A P08908 1/20 0.37
ADORA3 P0DMS8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6365734 0.96 MAOB (0.43) KMT2AMAOBNPC1RAB9ASMN1; SMN2
SCHEMBL66437 0.80 PTGS1 (0.42) MAOBNPC1RAB9ASMN1; SMN2MAPT
SCHEMBL1068810 0.80 KMT2A (0.41) KMT2AMAOBNPC1RAB9ASMN1; SMN2
SCHEMBL12384194 0.77 KMT2A (0.39) KMT2AMAOBNPC1RAB9ASMN1; SMN2
SCHEMBL8353535 0.76 NOTUM (0.41) KMT2AMAOBMAPTALDH1A1KDM4E
SCHEMBL3041896 0.75 HPGD (0.51) KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1
Biphenyl SCHEMBL3362977 0.73 ALDH1A1 (0.38) KMT2AMAOBNPC1RAB9ASMN1; SMN2
SCHEMBL5805130 0.71 TDP1 (0.38) KMT2AMAOBNPC1RAB9ASMN1; SMN2
SCHEMBL9322971 0.71 KIF11 (0.46) SMN1; SMN2MAPTALDH1A1KDM4ELMNA
SCHEMBL10712050 0.71 KMT2A (0.37) KMT2ANPC1RAB9AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019018795-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS (US) 2019-01-24 WO disclosed
WO-2017132701-A1 METHOD FOR SCREENING ANTIBODIES ZHANG SHUANG (US) 2017-08-03 WO disclosed
US-20170088625-A1 CD-20-SPECIFIC ANTIBODIES AND METHODS OF EMPLOYING SAME DUKE UNIVERSITY 2017-03-30 US disclosed
US-9416187-B2 CD-20 specific antibodies and methods of employing same DUKE UNIVERSITY (US) 2016-08-16 US disclosed
EP-2536746-B1 DISULPHIDE BOND-STABILIZED FUNCTIONAL SOLUBLE MHC CLASS II HETERODIMERS UNI I OSLO (NO) 2016-04-20 EP disclosed
EP-2960251-A1 CD20-specific antibodies and methods of employing same Duke University (US) 2015-12-30 EP disclosed
EP-2753604-B1 PDE10 MODULATORS HOFFMANN LA ROCHE (CH) 2015-08-19 EP disclosed
US-9056920-B2 Disulphide bond-stabilized functional soluble MHC class II heterodimers UNIVERSITETET I OSLO (NO) 2015-06-16 US disclosed
EP-1626993-B1 CD20-SPECIFIC ANTIBODIES AND METHODS OF EMPLOYING SAME UNIV DUKE (US) 2015-03-11 EP disclosed
US-8969253-B2 Method for screening phage display libraries against each other NEXTERA AS (NO) 2015-03-03 US disclosed
US-5610034-A Immunoglobulin production by trichoderma ALKO GROUP LTD. (FI) 1997-03-11 US disclosed
EP-0659215-A1 PRODUCTION OF PHYTATE DEGRADING ENZYMES IN $i(TRICHODERMA) Alko Group Ltd. (FI) 1995-06-28 EP disclosed
EP-0630968-A2 Genetic selection of proteins able to bind a ligand by signal-transduction in a microorganism BEHRINGWERKE Aktiengesellschaft (DE) 1994-12-28 EP disclosed
WO-1994003612-A1 PRODUCTION OF PHYTATE DEGRADING ENZYMES IN $i(TRICHODERMA) PRIMALCO OY (FI) 1994-02-17 WO disclosed
EP-0539395-A1 IMMUNOGLOBULIN PRODUCTION BY $i(TRICHODERMA) Alko Group Ltd. (FI) 1993-05-05 EP disclosed
WO-1993002198-A1 RECOMBINANT SECRETABLE FUSION PROTEINS TECHNICAL RESEARCH CENTRE OF FINLAND (FI) 1993-02-04 WO disclosed
EP-0494237-A1 A METHOD FOR THE IDENTIFICATION AND SELECTION OF ANTIBODY PRODUCING CELLS MEDICAL RESEARCH COUNCIL (GB) 1992-07-15 EP disclosed
WO-1992001797-A1 IMMUNOGLOBULIN PRODUCTION BY $i(TRICHODERMA) OY ALKO AB (FI) 1992-02-06 WO disclosed
WO-1991005260-A1 A METHOD FOR THE IDENTIFICATION AND SELECTION OF ANTIBODY PRODUCING CELLS MEDICAL RESEARCH COUNCIL (GB) 1991-04-18 WO disclosed
EP-0065217-A2 5-Haloalkyl-1,2,4-triazole and process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1982-11-24 EP disclosed