Biphenyl

Biphenyl

SCHEMBL3362977

C=C1COC(c2ccccc2)=N1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.38

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Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
LMNA P02545 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPT P10636 2/20 0.38
GAA P10253 1/20 0.38
KMT2A Q03164 2/20 0.34
MAOB P27338 2/20 0.34
NOTUM Q6P988 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
AKT1 P31749 1/20 0.32
AKT2 P31751 1/20 0.32
MMP9 P14780 1/20 0.32
MEN1 O00255 1/20 0.32
POLB P06746 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
ATM Q13315 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Biphenyl SCHEMBL3362574 0.78 ALDH1A1 (0.37) ALDH1A1NPC1RAB9ALMNAKDM4E
SCHEMBL10148452 0.77 NPC1 (0.40) ALDH1A1NPC1RAB9AKDM4EKMT2A
SCHEMBL12384194 0.76 KMT2A (0.39) ALDH1A1NPC1RAB9ALMNAKDM4E
SCHEMBL6365734 0.74 MAOB (0.43) ALDH1A1NPC1RAB9ALMNAKDM4E
SCHEMBL12946128 0.74 KIF11 (0.41) NOTUM
SCHEMBL84708 0.73 KMT2A (0.44) ALDH1A1NPC1RAB9ALMNAKDM4E
SCHEMBL9255758 0.71 LMNA (0.35) ALDH1A1NPC1RAB9ALMNAKDM4E
SCHEMBL2697682 0.65
Biphenyl SCHEMBL29384625 0.63 ALDH1A1 (0.90) ALDH1A1NPC1RAB9ALMNAMAPT
Biphenyl SCHEMBL29499038 0.63 ALDH1A1 (0.90) ALDH1A1NPC1RAB9ALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010034236-A1 PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) 2010-04-01 WO disclosed