SCHEMBL8470852

SCHEMBL8470852

COC[C@]1(n2cc(C)c(=O)[nH]c2=O)C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TK1 P04183 8/20 0.41
ALDH1A1 P00352 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
ALB P02768 1/20 0.37
PKM P14618 1/20 0.37
LMNA P02545 1/20 0.37
BLM P54132 1/20 0.37
PMP22 Q01453 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29597386 0.89 TK1 (0.39) TK1ALDH1A1NPSR1
SCHEMBL14388593 0.89 TK1 (0.43) TK1ALDH1A1ALBPKMLMNA
SCHEMBL27436150 0.89 TK1 (0.43) TK1ALDH1A1ALBPKMLMNA
SCHEMBL887851 0.88 TK1 (0.43) TK1ALDH1A1ALBPKMLMNA
SCHEMBL1517629 0.88 TK1 (0.44) TK1ALDH1A1ALBPKMLMNA
SCHEMBL28249854 0.87 TK1 (0.42) TK1ALDH1A1ALBPKMLMNA
SCHEMBL6923545 0.86 RNASE1 (0.41) TK1
SCHEMBL6923541 0.86 RNASE1 (0.41) TK1
SCHEMBL27602624 0.85 TK1 (0.43) TK1ALBPKMLMNABLM
SCHEMBL8299476 0.85 TYMP (0.44) TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1122040-C Suger modified nucleosides and their use for synthesis of oligonucleotides ICN PHARMACEUTICALS (US) 2003-09-24 CN disclosed
EP-0789706-A4 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1999-08-11 EP disclosed
CN-1170412-A Suger modified nucleosides and their use for synthesis of oligonucleotides ICN PHARMACEUTICALS (US) 1998-01-14 CN disclosed
EP-0789706-A1 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1997-08-20 EP disclosed
WO-1996014329-A1 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1996-05-17 WO disclosed