Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476064 | 0.97 | KDM4E (0.44) | KDM4ESMN1; SMN2HIF1ACNR2CHRM2 | |
| SCHEMBL8473304 | 0.94 | KDM4E (0.46) | KDM4ESMN1; SMN2CNR2NPC1RAB9A | |
| SCHEMBL8475760 | 0.94 | KDM4E (0.46) | KDM4ESMN1; SMN2CNR2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8474427 | 0.94 | KDM4E (0.46) | KDM4ESMN1; SMN2CNR2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8472265 | 0.93 | KDM4E (0.44) | KDM4ESMN1; SMN2CNR2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8472403 | 0.91 | KDM4E (0.42) | KDM4ESMN1; SMN2CNR2KCNH2NPC1 | |
| Hydrochloric Acid SCHEMBL8472257 | 0.89 | KDM4E (0.42) | KDM4ESMN1; SMN2CNR2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8479395 | 0.89 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2CNR2HTR6ALDH1A1 | |
| SCHEMBL8476147 | 0.86 | TSHR (0.49) | KDM4ESMN1; SMN2CNR2CCR5TSHR | |
| SCHEMBL8477083 | 0.86 | CYP3A4 (0.49) | KDM4ESMN1; SMN2CNR2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0782989-A1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |