Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 6/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477083 | 0.98 | CYP3A4 (0.49) | TSHRCYP3A4CYP2D6TP53CYP1A2 | |
| SCHEMBL8472493 | 0.87 | KDM4E (0.52) | TSHRCYP3A4CYP2D6TP53CYP1A2 | |
| SCHEMBL8472271 | 0.87 | HRH3 (0.47) | TP53CNR2CNR1KDM4ESMN1; SMN2 | |
| SCHEMBL8472267 | 0.86 | KDM4E (0.45) | TSHRCYP3A4CYP2D6CNR2CNR1 | |
| SCHEMBL8476064 | 0.85 | KDM4E (0.44) | TSHRCYP3A4CYP2D6CNR2CNR1 | |
| SCHEMBL8898545 | 0.84 | CNR2 (0.44) | TDP1CNR2KDM4ELMNA | |
| SCHEMBL8475760 | 0.84 | KDM4E (0.46) | TSHRCYP3A4CYP2D6TP53CYP1A2 | |
| SCHEMBL8472179 | 0.84 | KDM4E (0.48) | TSHRCYP3A4CYP2D6TP53CYP1A2 | |
| SCHEMBL8473304 | 0.84 | KDM4E (0.46) | TSHRCYP3A4CYP2D6TP53CYP1A2 | |
| SCHEMBL8477838 | 0.84 | CNR2 (0.48) | CNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0782989-A1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |