SCHEMBL8473000

SCHEMBL8473000

O=C(O)CCSc1cccc(F)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.51
PTGER1 P34995 1/20 0.46
PTGFR P43088 1/20 0.46
EPHX1 P07099 1/20 0.44
APEX1 P27695 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
SLC6A9 P48067 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
GRM2 Q14416 1/20 0.41
GRM3 Q14832 1/20 0.41
FFAR1 O14842 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PRNP P04156 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
RXFP1 Q9HBX9 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4027432 0.90 ALDH1A1 (0.67) ALDH1A1PTGER1PTGFREPHX1APEX1
SCHEMBL5718731 0.89 ALDH1A1 (0.60) ALDH1A1PTGER1PTGFREPHX1APEX1
SCHEMBL4541223 0.87 ALDH1A1 (0.58) ALDH1A1PTGER1PTGFREPHX1APEX1
SCHEMBL6423149 0.83 PTGS2 (0.46) ALDH1A1PTGER1FFAR1LMNAHTT
SCHEMBL4278929 0.82 APEX1 (0.64) ALDH1A1PTGER1PTGFREPHX1APEX1
SCHEMBL22714458 0.81 ALDH1A1 (0.53) ALDH1A1APEX1CYP1A2CYP3A4CYP2D6
SCHEMBL11605014 0.79 ALDH1A1 (0.51) ALDH1A1APEX1CYP1A2CYP3A4CYP2D6
SCHEMBL5447638 0.79 ALDH1A1 (0.51) ALDH1A1APEX1CYP1A2CYP3A4CYP2D6
SCHEMBL2776945 0.79 MAPT (0.53) ALDH1A1PTGER1PTGFRAPEX1CYP1A2
SCHEMBL4408369 0.79 ALDH1A1 (0.51) ALDH1A1PTGFRAPEX1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5886016-A ANTIINFLAMMATORY AGENT WITH MINIMAL SIDE EFFECTS FOR TREATING ARTHRITIS G.D. SEARLE & CO. (US) 1999-03-23 US disclosed
US-5670532-A Pyrazolyl derivatives for the treatment of inflammation G. D. SEARLE & CO. (US) 1997-09-23 US disclosed
US-5565482-A ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS G.D. SEARLE & CO. (US) 1996-10-15 US disclosed
US-5547975-A ANTIARTHRIC AGENTS, ANALGESICS AND ANTIPYRETICS; INHIBITORS OF CYCLOOXYGENASE II; SIDE EFFECT REDUCTION G.D. SEARLE & CO. 1996-08-20 US disclosed
WO-1996009304-A1 BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-03-28 WO disclosed