Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2361098 | 0.85 | HTT (0.91) | HTTSMN1; SMN2ALOX12NPC1RAB9A | |
| SCHEMBL8476275 | 0.80 | CDK2 (0.64) | HTTL3MBTL1EPHX1ALDH1A1POLB | |
| SCHEMBL6442708 | 0.78 | EPHX1 (0.73) | HTTL3MBTL1EPHX1ALDH1A1POLB | |
| SCHEMBL8590214 | 0.78 | ALOX12 (1.00) | HTTSMN1; SMN2ALOX12NPC1RAB9A | |
| SCHEMBL8556765 | 0.78 | L3MBTL1 (0.68) | HTTL3MBTL1USP2EPHX1ALDH1A1 | |
| SCHEMBL8478839 | 0.77 | L3MBTL1 (0.61) | HTTL3MBTL1USP2EPHX1ALDH1A1 | |
| SCHEMBL29098671 | 0.77 | GAA (0.70) | HTTSMN1; SMN2ALOX12L3MBTL1NPC1 | |
| SCHEMBL10362736 | 0.77 | GAA (0.70) | HTTSMN1; SMN2ALOX12L3MBTL1NPC1 | |
| SCHEMBL10363617 | 0.77 | GAA (0.70) | HTTSMN1; SMN2ALOX12L3MBTL1NPC1 | |
| SCHEMBL8777804 | 0.76 | L3MBTL1 (0.60) | HTTSMN1; SMN2L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872115-A | COMPOUNDS FOR TREATMENT OF HYPERCHOLESTEROLEMIA, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISEASE OR ATHEROSCLEROSIS | GRELAN PHARMACEUTICAL CO. LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| EP-0742208-A1 | 2-Ureido-benzamide derivatives | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1996-11-13 | — | — | EP | disclosed |