Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.56 |
| ▸ | EDNRA | P25101 | 10/20 | 0.56 |
| ▸ | NAT1 | P18440 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479006 | 0.87 | EDNRB (0.60) | EDNRBEDNRAMAPTALDH1A1KDM4E | |
| SCHEMBL8474456 | 0.86 | EDNRB (0.58) | EDNRBEDNRANAT1MAPTTP53 | |
| SCHEMBL8474213 | 0.81 | EDNRB (0.56) | EDNRBEDNRALMNATSHRMAPK1 | |
| SCHEMBL8475736 | 0.81 | ALDH1A1 (0.59) | EDNRBEDNRANAT1PGRMAPT | |
| SCHEMBL4030049 | 0.80 | MAPT (0.60) | MAPTTP53ALDH1A1KDM4EMAPK1 | |
| SCHEMBL8473889 | 0.79 | EDNRB (0.54) | EDNRBEDNRAMAPTTSHRMAPK1 | |
| SCHEMBL6170416 | 0.74 | PTGS1 (0.60) | MAPTTP53ALDH1A1KDM4ETSHR | |
| SCHEMBL8478773 | 0.74 | MCL1 (0.46) | EDNRBEDNRAALDH1A1KDM4ETSHR | |
| SCHEMBL23631845 | 0.73 | PGR (0.59) | EDNRBEDNRAPGRALDH1A1PKM | |
| SCHEMBL14711514 | 0.73 | LPAR1 (0.59) | EDNRBEDNRAMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |