Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | BRD2 | P25440 | 2/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474214 | 0.90 | BRD4 (0.47) | BRD4BRD2BRD3PTGS2ALOX5AP | |
| SCHEMBL8479007 | 0.90 | EDNRB (0.46) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8473891 | 0.88 | PTGS2 (0.45) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8474223 | 0.87 | KMT2A (0.48) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8474687 | 0.81 | PTGS2 (0.57) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8479976 | 0.80 | BRD4 (0.47) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL6170394 | 0.79 | CA1 (0.54) | PTGS1PTGS2ALOX5APCA2CA9 | |
| SCHEMBL6170551 | 0.79 | CA1 (0.54) | PTGS1PTGS2ALOX5APCA2CA9 | |
| SCHEMBL8474145 | 0.79 | BRD4 (0.49) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8473322 | 0.78 | PTGS2 (0.46) | BRD4BRD2BRD3PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |