Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 2/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 3/20 | 0.41 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474458 | 0.87 | BRD4 (0.45) | RAB9ABRD4BRD2BRD3F10 | |
| SCHEMBL8479007 | 0.86 | EDNRB (0.46) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8475740 | 0.82 | PTGS2 (0.64) | KMT2ARAB9ABRD4BRD2BRD3 | |
| SCHEMBL8474214 | 0.82 | BRD4 (0.47) | BRD4BRD2BRD3F10PTGS2 | |
| SCHEMBL6169441 | 0.81 | CA2 (0.55) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8473891 | 0.80 | PTGS2 (0.45) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL8474145 | 0.79 | BRD4 (0.49) | BRD4BRD2BRD3PTGS1PTGS2 | |
| SCHEMBL6170416 | 0.78 | PTGS1 (0.60) | RAB9ABRD4BRD2PTGS1PTGS2 | |
| SCHEMBL22587920 | 0.77 | PTGES2 (0.50) | KMT2ARAB9AF10PTGS1PTGS2 | |
| SCHEMBL29588398 | 0.77 | PTGES2 (0.50) | KMT2ARAB9AF10PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |