SCHEMBL8475264

SCHEMBL8475264

CC(CC=O)c1cnccn1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
LMNA P02545 1/20 0.34
CYP2D6 P10635 2/20 0.32
HRH1 P35367 2/20 0.32
KCNH2 Q12809 2/20 0.32
CHRM1 P11229 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
ATM Q13315 1/20 0.31
NAPRT Q6XQN6 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31
VNN1 O95497 1/20 0.30
HSP90AA1 P07900 1/20 0.30
FFAR2 O15552 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24975585 0.82 ESR1 (0.32)
SCHEMBL28822429 0.78 KDM4E (0.40) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL294332 0.76 RAB9A (0.41) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL12694263 0.76 RAB9A (0.41) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL10115951 0.76 RAB9A (0.41) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL13104826 0.76 RAB9A (0.41) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL295095 0.75 KDM4E (0.38) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL8427620 0.75 LMNA (0.37) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL5883220 0.74 TSHR (0.44) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6
SCHEMBL18595067 0.73 SMN1; SMN2 (0.37) KDM4EALDH1A1SMN1; SMN2LMNACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5939268-A DIELS-ALDER REACTION PRODUCT OF A DIENE AND A DIENOPHILE; CHEMICAL INTERMEDIATES FOR DRUGS, SOLID PHASE SYNTHESIS THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
EP-0773953-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS INSTITUTE (US) 1997-05-21 EP claimed
WO-1996003424-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS RESEARCH INSTITUTE (US) 1996-02-08 WO claimed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
CN-1183119-C Arylpiperzines as metalloproteinase inhibiting agents (MMP) and their use 2005-01-05 CN disclosed
CN-1324347-A Arylpiperzines as metalloproteinase inhibiting agents (MMP) and their use ASTRA ZENECA LTD (SE) 2001-11-28 CN disclosed
US-5939268-A DIELS-ALDER REACTION PRODUCT OF A DIENE AND A DIENOPHILE; CHEMICAL INTERMEDIATES FOR DRUGS, SOLID PHASE SYNTHESIS THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US disclosed
EP-0773953-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS INSTITUTE (US) 1997-05-21 EP disclosed
WO-1996003424-A1 COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME THE SCRIPPS RESEARCH INSTITUTE (US) 1996-02-08 WO disclosed