Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185723 | 0.81 | MAOA (0.41) | ALDH1A1KDM4EUSP2KMT2ARAB9A | |
| SCHEMBL5774143 | 0.81 | HTT (0.40) | ALDH1A1HIF1AKDM4EKMT2AHTT | |
| SCHEMBL3411071 | 0.81 | BCL2L1 (0.42) | ALDH1A1MAPTNPC1MAOAMAOB | |
| SCHEMBL5489563 | 0.79 | HPGD (0.45) | ALDH1A1KDM4EMAPTHTTMAOA | |
| SCHEMBL847542 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HIF1AKDM4EHTT | |
| SCHEMBL5200753 | 0.79 | PARP1 (0.43) | ALDH1A1KDM4EKMT2ARAB9AMAPT | |
| SCHEMBL5777797 | 0.79 | PBRM1 (0.42) | EGFRALDH1A1HIF1AKDM4EKMT2A | |
| SCHEMBL5779117 | 0.79 | MEP1B (0.41) | HIF1AKMT2AMAOAMAOB | |
| SCHEMBL290340 | 0.78 | CES2 (0.46) | ALDH1A1KMT2AMAPTHTTMAOA | |
| SCHEMBL5776042 | 0.78 | NOS1 (0.42) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427057-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129049-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2007001335-A2 | RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-5710157-A | INSECTICIDES FOR AGRICULTURE | FMC CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| US-5593998-A | 2,4-diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides | FMC CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| US-5547954-A | MIXED WITH AGRICULTURAL ACCEPTABLE CARRIER | FMC CORPORATION (US) | 1996-08-20 | — | — | US | disclosed |
| US-5532370-A | FOR INSECTS INCLUDING LARVAE SUCH AS TOBACCO BUDWORM | FMC CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |