Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PPID | Q08752 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1041487 | 0.91 | LMNA (0.56) | LMNACYP1A2CYP3A4MAOAMMP8 | |
| SCHEMBL11432797 | 0.88 | LMNA (0.53) | LMNACYP1A2CYP3A4MAOAMMP8 | |
| SCHEMBL13009601 | 0.86 | LMNA (0.51) | LMNACYP1A2CYP3A4MAOAMMP8 | |
| SCHEMBL9300518 | 0.86 | ALDH1A1 (0.47) | LMNACYP1A2CYP3A4MAOAMMP8 | |
| SCHEMBL1275691 | 0.84 | MMP8 (0.70) | MMP8CA12CA1CA2CA9 | |
| SCHEMBL5766034 | 0.83 | MMP8 (0.51) | LMNAMMP8ALDH1A1CA12CA1 | |
| SCHEMBL4064086 | 0.83 | MMP8 (0.51) | LMNACYP1A2CYP3A4MMP8ALDH1A1 | |
| SCHEMBL999787 | 0.83 | MMP8 (0.55) | LMNACYP1A2MMP8ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL10677191 | 0.82 | MMP8 (0.68) | MMP8CA12CA1CA2CA9 | |
| Ethane SCHEMBL27824026 | 0.82 | MMP8 (0.68) | MMP8CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925649-A | ANTIASTHMATIC LACTAM MACROLIDES | NOVARTIS AG (CH) | 1999-07-20 | — | — | US | disclosed |
| EP-0819130-A1 | ASCOMYCINS | Novartis AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031514-A1 | ASCOMYCINS | NOVARTIS AG (CH) | 1996-10-10 | — | — | WO | disclosed |