SCHEMBL8475995

SCHEMBL8475995

Nc1c(O)cc(S(=O)(=O)Oc2ccccc2)c2ccccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA9 Q16790 3/20 0.44
SLC7A11 Q9UPY5 2/20 0.42
LDHA P00338 1/20 0.40
CYP2C9 P11712 1/20 0.40
MCL1 Q07820 1/20 0.40
HSD17B10 Q99714 1/20 0.40
SUMO2 P61956 2/20 0.40
SUMO1 P63165 2/20 0.40
SENP7 Q9BQF6 2/20 0.40
SENP2 Q9HC62 2/20 0.40
SENP1 Q9P0U3 2/20 0.40
NT5E P21589 1/20 0.39
ITGA1 P56199 1/20 0.39
HKDC1 Q2TB90 1/20 0.38
SENP3 Q9H4L4 1/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11135876 0.86 CA1 (0.53) CA1CA2CA9SLC7A11LDHA
SCHEMBL10605483 0.79 LDHA (0.58) CA1CA2CA9LDHACYP2C9
SCHEMBL7535537 0.78 LDHA (0.58) CA1CA2CA9LDHAHSD17B10
SCHEMBL153735 0.77 NT5E (0.59) SLC7A11LDHASUMO2SUMO1SENP7
SCHEMBL11600779 0.76 MEN1 (0.56) CA1CA2CA9LDHAMCL1
SCHEMBL8502072 0.76 HKDC1 (0.55) LDHACYP2C9MCL1HSD17B10SUMO2
SCHEMBL8476304 0.76 HKDC1 (0.55) LDHACYP2C9MCL1HSD17B10SUMO2
SCHEMBL4113734 0.76 NT5E (0.57) SLC7A11LDHASUMO2SUMO1SENP7
SCHEMBL11573205 0.76 LDHA (0.46) SLC7A11LDHACYP2C9MCL1HSD17B10
SCHEMBL4113728 0.74 APP (0.54) SLC7A11LDHAHSD17B10NT5EHKDC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5936016-A SPIRO(INDOLINE(2,3')-NAPHTHOXAZINES) HAVING SPECIFIED SUBSTITUENT IN THE 6' POSITION; OPHTHALMIC OPTICS AND LENSES ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1999-08-10 US disclosed
EP-0772798-B1 SPIRO INDOLINE- 2,3']-BENZOXAZINE]-TYPE PHOTOCHROMIC COMPOUNDS CONTAINING A 6'-CYANO OR PHENYLSULPHONYL GROUP AND WITH A 7', 8'-CONDENSED BENZENE RING IN THE BENZOXAZINE RING AND USE OF SAME IN OPHTHALMIC OPTICS TRANSITIONS OPTICAL INC (US) 1999-06-02 EP disclosed
EP-0772798-A1 SPIRO INDOLINE- 2,3']-BENZOXAZINE]-TYPE PHOTOCHROMIC COMPOUNDS CONTAINING A 6'-CYANO OR PHENYLSULPHONYL GROUP AND WITH A 7', 8'-CONDENSED BENZENE RING IN THE BENZOXAZINE RING AND USE OF SAME IN OPHTHALMIC OPTICS ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1997-05-14 EP disclosed
WO-1996004590-A1 SPIRO[INDOLINE-[2,3']-BENZOXAZINE]-TYPE PHOTOCHROMIC COMPOUNDS CONTAINING A 6'-CYANO OR PHENYLSULPHONYL GROUP AND WITH A 7', 8'-CONDENSED BENZENE RING IN THE BENZOXAZINE RING AND USE OF SAME IN OPHTHALMIC OPTICS ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1996-02-15 WO disclosed