Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484905 | 0.94 | APP (0.47) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL5886251 | 0.83 | APP (0.40) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL5354756 | 0.82 | AR (0.39) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL7066508 | 0.80 | APP (0.39) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL1465878 | 0.80 | AKR1C3 (0.65) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL14446345 | 0.79 | OPRM1 (0.49) | — | |
| SCHEMBL2198459 | 0.78 | AKR1C3 (0.52) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL4823323 | 0.77 | TRPV4 (0.47) | TRPV4 | |
| SCHEMBL30842826 | 0.76 | APP (0.56) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL31759329 | 0.76 | APP (0.69) | APPAKR1C3AKR1C2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229034-B1 | Nicotinamide derivatives and their mimetics as inhibitors of PDE4 isozymes | PFIZER PROD INC (US) | 2005-04-13 | — | — | EP | disclosed |