Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.60 |
| ▸ | NOS3 | P29474 | 5/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 4/20 | 0.40 |
| ▸ | BRD2 | P25440 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.37 |
| ▸ | BRD8 | Q9H0E9 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469480 | 0.81 | NOS1 (0.36) | NOS1NOS3KCNH2 | |
| SCHEMBL8275696 | 0.81 | NOS1 (0.67) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL6710912 | 0.76 | NOS1 (1.00) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL6713246 | 0.70 | NOS1 (0.68) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL8275580 | 0.67 | NOS1 (0.76) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL8275965 | 0.67 | NOS1 (0.67) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL8275943 | 0.66 | NOS1 (0.80) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL194469 | 0.66 | NOS1 (1.00) | NOS1NOS3BRD9BRD4BRD7 | |
| SCHEMBL8275992 | 0.66 | NOS1 (0.61) | NOS1NOS3NOS2 | |
| SCHEMBL6713109 | 0.65 | NOS1 (1.00) | NOS1NOS3NOS2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | NOS3, NOS1, NOS2 | NOS1 2/4885NOS3 1/4885BRD9 4554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.