Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 9/20 | 0.63 |
| ▸ | PRKACG | P22612 | 9/20 | 0.63 |
| ▸ | PRKACB | P22694 | 9/20 | 0.63 |
| ▸ | PRKCA | P17252 | 5/20 | 0.63 |
| ▸ | PRKCB | P05771 | 4/20 | 0.63 |
| ▸ | CDK4 | P11802 | 3/20 | 0.63 |
| ▸ | CCND1 | P24385 | 3/20 | 0.63 |
| ▸ | PRKCH | P24723 | 3/20 | 0.63 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.63 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.63 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gf-109203 SCHEMBL338086 | 0.77 | PRKACA (1.00) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| Gf-109203 SCHEMBL29353725 | 0.77 | PRKACA (1.00) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| SCHEMBL7199461 | 0.77 | PRKACA (0.81) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| SCHEMBL8476627 | 0.77 | PRKCB (0.46) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| Gf-109203 SCHEMBL29534077 | 0.77 | PRKACA (0.98) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| Gf-109203 SCHEMBL1199513 | 0.77 | PRKACA (0.98) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| SCHEMBL2945611 | 0.76 | PRKCA (0.53) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| SCHEMBL16576315 | 0.75 | PRKACA (0.72) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| SCHEMBL7815621 | 0.75 | PRKACA (0.81) | PRKACAPRKACGPRKACBPRKCAPRKCB | |
| Hydrochloric Acid SCHEMBL9085195 | 0.75 | PRKACA (0.80) | PRKACAPRKACGPRKACBPRKCAPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5936084-A | ANTIDIABETIC,-ISCHEMIA AND -INFLAMMATORY AGENTS; CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR AND SKIN DISORDERS; ANTITUMORAND-CARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| US-5821365-A | COMPOUNDS AS ENZYME INHIBITORS FOR KINASES FORMED BY REACTION OF AMINE WITH ANHYDRIDE GROUP TO FORM INDOLMALEIMIDE MACROCYCLES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5780461-A | ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| US-5739322-A | INHIBITORS OF PROTEIN KINASE C IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-14 | — | — | US | disclosed |
| US-5719175-A | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-5698578-A | BIS-INDOLEMALEIMIDE MACROCYCLE DERIVATIVES; TREATMENT OF DIABETES | ELI LILLY AND COMPANY (US) | 1997-12-16 | — | — | US | disclosed |
| US-5696108-A | ADMINISERING TO THE MAMMAL BIS-INDOLEMALEIMIDE MACROCYCLIC DERIVATIVE AS ANTIINFLAMMATORY AGENT | ELI LILLY AND COMPANY (US) | 1997-12-09 | — | — | US | disclosed |
| US-5674862-A | USING A BIS(INDOLEMALEIMIDE) MACROCYCLE DERIVATIVE | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| US-5672618-A | TREATING DIABETIC COMPLICATIONS | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |