Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947288 | 1.00 | CHRNA7 (0.40) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL6171825 | 0.85 | DHFR (0.41) | MEN1KMT2A | |
| SCHEMBL6171832 | 0.85 | DHFR (0.41) | MEN1KMT2A | |
| SCHEMBL6951153 | 0.82 | CHRNA7 (0.43) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL8163118 | 0.78 | CHRNA7 (0.39) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7833545 | 0.78 | CHRNA7 (0.39) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL6171726 | 0.78 | STAT3 (0.34) | NPC1RAB9ACYP2A6 | |
| SCHEMBL5016747 | 0.78 | CHRNA7 (0.57) | CHRNA7L3MBTL1TDP1CYP2A6TBXAS1 | |
| SCHEMBL7978396 | 0.76 | MEN1 (0.36) | TDP1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7978399 | 0.76 | MEN1 (0.36) | TDP1NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977105-A | Compounds | ASTRA PHARMAEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |