Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL846022 | 0.87 | TRPV1 (0.43) | TRPV1TNKSTNKS2KDRNPC1 | |
| SCHEMBL846354 | 0.85 | TRPV1 (0.44) | TRPV1TNKSTNKS2KDRNPC1 | |
| SCHEMBL847500 | 0.80 | TRPV1 (0.46) | MCHR1HTR2CTRPV1KDRNPC1 | |
| SCHEMBL845899 | 0.77 | TRPV1 (0.47) | TRPV1KDRNPC1RAB9AKDM4E | |
| SCHEMBL845882 | 0.75 | TRPV1 (0.43) | TRPV1KDRNPC1RAB9AKDM4E | |
| SCHEMBL846567 | 0.74 | TRPV1 (0.48) | MCHR1TRPV1KDRNPC1RAB9A | |
| SCHEMBL846149 | 0.73 | TRPV1 (0.60) | TRPV1KDRNPC1RAB9AKDM4E | |
| SCHEMBL846941 | 0.73 | RAB9A (0.59) | NPC1RAB9AKDM4EKLF5ALDH1A1 | |
| SCHEMBL846600 | 0.73 | TRPV1 (0.65) | TRPV1KDRNPC1RAB9AKDM4E | |
| SCHEMBL847872 | 0.71 | TNKS (0.44) | TNKSTNKS2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |