Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481711 | 0.91 | PDE4D (0.46) | PDE4DPPARDEGFRXDHMRGPRX4 | |
| SCHEMBL8476993 | 0.85 | EGFR (0.40) | PDE4DPPARDEGFRXDHNEK2 | |
| SCHEMBL8479735 | 0.84 | MRGPRX4 (0.41) | PDE4DPPARDEGFRXDHMRGPRX4 | |
| SCHEMBL8480273 | 0.83 | MRGPRX4 (0.41) | PDE4DEGFRMRGPRX4RARG | |
| SCHEMBL8482087 | 0.74 | CTSA (0.45) | PDE4DCTSADCLRE1B | |
| SCHEMBL8478791 | 0.74 | EGFR (0.36) | EGFR | |
| SCHEMBL8481030 | 0.73 | LMNA (0.44) | PDE4DPTGS2NEK2 | |
| SCHEMBL5988362 | 0.68 | CNR2 (0.46) | PDE4DEGFRXDHRARG | |
| SCHEMBL2475768 | 0.68 | FABP4 (0.41) | EGFRXDHMRGPRX4 | |
| SCHEMBL13125274 | 0.68 | LMNA (0.68) | EGFRXDHMRGPRX4RARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |