Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934862 | 0.83 | MAPT (0.55) | TDP1TSHRAPPADRB2ADRB1 | |
| SCHEMBL6141129 | 0.83 | TDP1 (0.52) | TDP1TSHRAPPADRB2ADRB1 | |
| SCHEMBL8740822 | 0.79 | USP2 (0.54) | TSHRMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL1759561 | 0.79 | CYP2C9 (0.56) | TSHRADRB3MAPTGAASMN1; SMN2 | |
| SCHEMBL1759547 | 0.79 | TSHR (0.45) | TSHRAPPMAOBMAPTMAOA | |
| SCHEMBL6912197 | 0.79 | LMNA (0.64) | TDP1TSHRAPPADRB2ADRB1 | |
| SCHEMBL8747584 | 0.79 | CYP1A2 (0.53) | TSHRRAB9AALDH1A1NPC1LMNA | |
| SCHEMBL124652 | 0.78 | LMNA (0.63) | TSHRADRB2ADRB1ADRB3MAPT | |
| SCHEMBL656178 | 0.78 | AR (0.53) | TDP1TSHRAPPADRB2ADRB1 | |
| SCHEMBL7124072 | 0.78 | TDP1 (0.47) | TDP1TSHRAPPADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5871709-A | TETRAAZACYCLODODECANE COMPOUNDS SUBSTITUTED WITH ALKYL CARBOXY COMPOUNDS FOR CARDIOVASCULAR DISORDERS AND BRAIN TUMORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-02-16 | — | — | US | claimed |